Tesamorelin

Tesamorelin · 20mg

Research peptide

GHRH analog (FDA) · visceral fat

Strong evidence
Molecule approved in United States and Canada · 2010What this means ›
🇺🇸 United States · Approved🇨🇦 Canada · Approved

The molecule is approved as a medicine in United States and Canada, under the brand Egrifta. Approved to reduce abdominal visceral fat in HIV-associated lipodystrophy (FDA, 2010; the Egrifta WR presentation since March 2025; Health Canada under the same brand). It is the only growth-hormone-axis compound with approval.

What is approved is the molecule under that pharmaceutical brand. Our vial is research material (RUO).

Source: FDA · Egrifta (2010), Egrifta WR (mar 2025) · Health Canada · Egrifta

Overview

What has it been researched for?

  • Reduces visceral belly fat Main focusStrong evidence
  • Improves lipids and blood pressureStrong evidence
  • Adds lean massStrong evidence
  • Raises GH and IGF-1 physiologicallyStrong evidence
  • Reduces liver fatStrong evidence
  • Attention, memory and less mental fatigueStrong evidence

Research protocols

The SBL research protocol and what the literature reports. Not medical advice.

SBL research protocol · no established clinical regimen in people

Dose
1 mg
Frequency
5-on / 2-off
Duration
12 weeks
Route
Subcutaneous
Evidence level
Approved

Tools

Evidence and studies

See studies →

Protocols

Research protocols

SBL research protocol · no established clinical regimen in people

Research use, with no established clinical regimen in people.

Dose
1 mg
Frequency
5-on / 2-off
Timing
noche
Duration
12 weeks
Break
4 weeks
Route
Subcutaneous
Evidence level
Approved

Example dose

0153010
10 u= 1 mg

30-unit U-100 insulin syringe · Starting dose of its protocol, with 2 ml of water in the 20 mg vial.

What it pairs with

  • Tirzepatide With a GLP-1 it targets the visceral belly fat the scale cannot tell apart.

Preparation and dosing

Quick reference

Vial20 mg
Diluent2 ml
Concentration10 mg/ml
1 unit =0.1 mg

Preparation

Diluent
Bacteriostatic water

Open calculator →See the guide →

Evidence

Each effect with its evidence level and, where available, its source.

Strong evidence(6)Moderate evidence(0)Early evidence(0)
  • Reduces visceral belly fatApprovedSee study · 2007
  • Improves lipids and blood pressureHuman studySee study · 2010
  • Adds lean massHuman studySee study · 2026
  • Raises GH and IGF-1 physiologicallyHuman studySee study · 2011
  • Reduces liver fatHuman studySee study · 2019
  • Attention, memory and less mental fatigueHuman studySee study · 2012

The science

Mechanisms, studies and references

GHRH analog

Safety

It makes sense if you want

  • Trim your waistline
  • More muscle, strength & composition
  • Lose weight — most potent

It does not make sense if

  • Pituitary surgery, tumour or radiation
  • Active cancer or oncology treatment in the last 5 years
  • Pregnancy or breastfeeding

Talk to your doctor first if this applies (9)

  • Severe untreated sleep apnea
  • Severe heart disease or recent cardiac event
  • Oral or injected corticosteroids (prednisone, dexamethasone)
  • Type 2 diabetes / prediabetes
  • Immunosuppressants
  • Insulin
  • Planning a pregnancy in the next 3 months
  • Diabetic retinopathy
  • Sulfonylureas / metformin

The certificate of analysis (CoA) certifies the identity and purity of the batch. It does not certify safety of use.

Verify your batch →

For research use only (RUO). This consult is educational and does not replace your doctor.

Questions

Frequently asked questions

What is it reconstituted with, and how much?

With bacteriostatic water: 2 ml into the 20 mg vial, giving 10 mg/ml.

What is the starting dose of the research protocol?

1 mg, 5-on / 2-off. This is the SBL research protocol, with no established clinical regimen in people.

How long is the cycle, and how long does a vial last?

12 weeks ON / 4 weeks OFF. At the starting dose, the 20 mg vial lasts ~4 sem.

Which route is used in research?

Subcutaneous.

When does it make no sense?

It makes no sense with: Pituitary surgery, tumour or radiation, Active cancer or oncology treatment in the last 5 years, Pregnancy or breastfeeding. Details in the Safety tab.

What is it combined with?

It goes well with Tirzepatide. The reasons are in the Protocols tab.

How do I check my batch?

With the code on the vial, in the verifier. The CoA certifies the identity and purity of the batch, not safety of use.

Verify your batch →

See kit

For research use only (RUO). This consult is educational and does not replace your doctor.