MOTS-c 10mg
Mitochondrial peptide · activates AMPK · cellular energy regulation
For research use only (RUO)
Ships from Quito · EC 1-3 days · LATAM 4-10
Arrives damaged? We replace it free
COA per batch4 mechanisms. Mitochondrial origin.
MOTS-c is one of the few endogenous peptides encoded by mitochondrial DNA (12S rRNA gene), not nuclear DNA. That makes it unique.
Activates AMPK
Same pathway as metformin but through a different mechanism. AMPK regulates global cellular energy metabolism.
Glucose ↓
Improves glucose regulation and insulin sensitivity. Useful in pre-diabetes and metabolic syndrome.
Fat oxidation
Increases beta-oxidation of fatty acids. Useful in a metabolic stack for multi-pathway weight loss.
Mitochondrial function
Levels decline with age, associated with metabolic deterioration. Studies in longevity and chronic fatigue.
Combine with.
MOTS-c shines in metabolic stacks. With a unique mechanism (AMPK), it adds up without overlapping with GLP-1.
If you take metformin, consult your physician before combining — they can potentiate each other.
Technical description.
MOTS-c (Mitochondrial Open Reading frame of the Twelve S rRNA-c) is a peptide encoded by mitochondrial DNA — one of the few endogenous peptides that originate in the mitochondria rather than the nuclear genome. This unique trait makes it a particularly interesting research tool in metabolic medicine and longevity.
SuperBio Labs MOTS-c is supplied as lyophilized powder with verified HPLC ≥99% purity. Each lot ships with an independent Certificate of Analysis confirming identity by LC-MS, peptide content (98–102%), and endotoxin levels (<1.0 EU/mg).
Its primary mechanism is activation of the AMPK pathway (AMP-activated protein kinase), the same pathway as metformin but through a different mechanism. AMPK is the "master switch" of cellular energy metabolism — when activated, it improves glucose regulation, fatty-acid oxidation, and mitochondrial biogenesis. Endogenous MOTS-c levels decline with age and are associated with age-related metabolic deterioration. In the research community it is considered part of the "modern metabolic stack 2026," typically combined with GLP-1/GIP agonists for multi-pathway weight loss.
Producto para uso profesional informado.
Complete kit · ready to reconstitute.
Each order includes everything needed for the 4-week cycle. No separate purchases required.
How to choose where to buy peptides.
This product meets all five — your batch COA ships with the kit.
Recommended application protocol.
Conservative protocol included in the kit. If you take metformin or insulin, consult your physician before starting.
When to use MOTS-c.
Stack with GLP-1
Multi-pathway addition with Tirz/Reta for more efficient weight loss.
Insulin resistance
Pre-diabetes, metabolic syndrome, elevated A1c.
Athletic performance
Endurance · oxidative capacity · aerobic pre-workout.
Longevity
Mitochondrial function declines with age · biohacker protocol.
Fatty liver
MASLD/MASH · improves hepatic markers.
Chronic fatigue
Mitochondrial dysfunction · CFS, long-COVID, severe burnout.
Honest side effects.
Very well tolerated. No serious effects documented in the research literature:
Rarely mild hypoglycemia if combined with metformin or insulin (consult a physician if you take either) · initial fatigue during the first week as the body adapts to the metabolic shift · no significant systemic effects in studies.
Technical specifications
| Product | MOTS-c |
| CAS Number | 1627580-64-6 |
| Molecular Weight | 1933 Da |
| Purity (HPLC) | ≥99% |
| Format | Lyophilized powder |
| Quantity | 10mg per vial |
| Origin | Mitochondrial (12S rRNA) |
| Endotoxins | <1.0 EU/mg |
| Storage | −20 °C, protected from light |
| Use | Uso bajo criterio profesional |