ACTH(4-10) analog heptapeptide · Russian nootropic · neuroplasticity
Semax was developed at the Russian Academy of Sciences in the 1980s. It is part of the Russian medical formulary for ischemic stroke. 40+ years of clinical use.
Increases Brain-Derived Neurotrophic Factor and NGF within hours. It is the fastest and most selective BDNF activator documented in the nootropic literature.
Modulates dopamine and serotonin without stimulating cortisol. Subjective effect: "clean" focus without the typical tension of caffeine or stimulants.
Improves working memory and long-term learning consolidation. Documented in Russian studies for students and high-demand professionals.
Reduces oxidative neural damage. Used in Russian protocols after mild stroke and head trauma. Antioxidant action specific to brain tissue.
Semax is a powerful standalone nootropic. Combining it with longevity or metabolic peptides amplifies the cognitive reset.
Any combination must respect the protocol for each peptide. If you have questions, write to us before you start.
Semax is a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) analog of the ACTH(4-10) fragment — the non-steroidal portion of adrenocorticotropic hormone. It was developed at the Institute of Molecular Genetics of the Russian Academy of Sciences in the 1980s and has been part of the Russian medical formulary since 1996 (for ischemic stroke and cognitive disorders).
SuperBio Labs Semax is supplied as lyophilized powder with verified HPLC purity ≥99%. Each lot ships with an independent Certificate of Analysis confirming identity by LC-MS, peptide content (98–102%), and endotoxin levels (<1.0 EU/mg).
Unlike classic stimulants (caffeine, modafinil), Semax does not raise cortisol and does not produce rapid tolerance. Its dual mechanism — increased BDNF/NGF + dopaminergic modulation — produces a state of deep, clean focus with lasting benefits to memory and plasticity. It is one of the most widely used nootropics among high-demand professionals (surgeons, traders, engineers) in the European biohacker community since the mid-2010s.
Producto para uso profesional informado.
Every order includes everything needed for the cycle. Nothing to buy separately.
This product meets all five — your batch COA ships with the kit.
Semax allows two routes: nasal (most common in Russia) or subcutaneous. Both are valid — the dose is adjusted depending on the route.
Do not administer after 4:00 PM — it may interfere with sleep onset in sensitive individuals. If used nasally, alternate nostrils between doses to avoid local irritation.
2-4 week cycle with cognitive response from day 1.
Surgeons, traders, engineers · 6-8 hours of deep focus · no caffeine peak-and-crash.
Improved memory consolidation · long-term retention · 2-4 week cycle for exam season.
Post-burnout · chronic brain fog · post-COVID mental fatigue · BDNF reset.
Focus without adrenergic stimulation · no tolerance · biohacker-community alternative to methylphenidate.
Documented in Russian post-stroke protocols · neuroprotection · language and memory recovery.
Modulates dopamine without raising cortisol · subtle anxiolytic effect · useful before presentations or exams.
Very well tolerated. Excellent safety profile over 40+ years of Russian clinical use:
If used nasally: local irritation of the nasal mucosa (alternate nostrils, use divided dosing) · occasional nasal dryness · sneezing on first application · mild stimulation if applied late (avoid after 4:00 PM) · no documented increase in blood pressure · no tolerance development when cycles are respected (2-4 weeks + 2-week break).
| Product | Semax (ACTH(4-10) analog) |
| CAS Number | 80714-61-0 |
| Molecular Weight | 813.92 Da |
| Sequence | Met-Glu-His-Phe-Pro-Gly-Pro |
| Purity (HPLC) | ≥99% |
| Format | Lyophilized powder |
| Quantity | 30mg per vial |
| Origin | Russian Academy of Sciences (Institute of Molecular Genetics) |
| Endotoxins | <1.0 EU/mg |
| Storage | −20 °C, protected from light |
| Use | Uso bajo criterio profesional |